asked

A 60-year-old female with chronic lymphocytic leukemia (CLL) and accompanying B symptoms is preparing to start treatment with Imbruvica after a routine colonoscopy revealed a hard bony prominence during a rectal exam. An 8mm polyp was removed from the mid-sigmoid, and the remaining mucosa appears normal. There is extrinsic compression seen in the rectum with a hard contour on palpation. The patient has a history of cerebral aneurysms (internal carotid; clipped 25 years ago), a recent CTA of the head as a precaution due to the risk of cerebral hemorrhage from Imbruvica, a history of L4-L5 laminectomy, Graves Disease (resolved without treatment), a subcutaneous catheter (SSC) removed from the right arm, CLL diagnosed in 2014, intermittent abnormal liver function tests (LFTs), a liver ultrasound showing a polyp on the gallbladder and splenomegaly, and a strong family history of ovarian cancer. The patient has gained 10lbs in the last two months, which is unusual for her. What could the hard bony prominence be, and should the patient be concerned about ovarian cancer?

March 11th, 2023

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